Endocrine Abstracts

The pituitary gland harbors stem cells whose role and regulation remain poorly understood. We recently established organoids from (mouse) pituitary as a novel research model to study pituitary stem cell biology (Cox et al., J Endocrinol 2019). Organoids represent 3D in vitro cell structures that self-develop from tissue stem cells under defined culture conditions, and that reproduce multiple aspects of the original healthy or diseased tissue. Organoi...

The pituitary is the ‘master’ endocrine gland, governing the fundamental processes of body growth, metabolism, reproduction and stress. The past decade, it progressively became clear that the pituitary, like many adult tissues, harbors a population of stem cells. While the molecular portrayal of these cells is continually expanding, their function remains essentially hidden. From recent studies, the picture is emerging that the stem cells of the adult pituitary are h...

Endocr Relat Cancer August 1, 2015 22 481–504. DOI: 10.1530/ERC-14-0546...